PlantImRecepV1, Main, Exploration, bibRecord, 000167

EGCG down-regulates MuRF1 expression through 67-kDa laminin receptor and the receptor signaling is amplified by eriodictyol.

Identifieur interne : 000167 ( Main/Exploration ); précédent : 000166; suivant : 000168

EGCG down-regulates MuRF1 expression through 67-kDa laminin receptor and the receptor signaling is amplified by eriodictyol.

Auteurs : Motoki Murata [Japon] ; Yuki Shimizu [Japon] ; Yuki Marugame [Japon] ; Ayaka Nezu [Japon] ; Konatsu Fujino [Japon] ; Shuhei Yamada [Japon] ; Motofumi Kumazoe [Japon] ; Yoshinori Fujimura [Japon] ; Hirofumi Tachibana [Japon]

Source :

Journal of natural medicines [ 1861-0293 ] ; 2020.

RBID : pubmed:32472528

Descripteurs français

KwdFr :
- Animaux (MeSH), Catéchine (analogues et dérivés), Catéchine (composition chimique), Flavanones (métabolisme), Plantes (composition chimique), Protéines du muscle (métabolisme), Protéines à motif tripartite (métabolisme), Récepteur laminine (métabolisme), Régulation négative (MeSH), Souris (MeSH), Transduction du signal (MeSH), Ubiquitin-protein ligases (métabolisme).
MESH :
- analogues et dérivés : Catéchine.
- composition chimique : Catéchine, Plantes.
- métabolisme : Flavanones, Protéines du muscle, Protéines à motif tripartite, Récepteur laminine, Ubiquitin-protein ligases.
- Animaux, Régulation négative, Souris, Transduction du signal.

English descriptors

KwdEn :
- Animals (MeSH), Catechin (analogs & derivatives), Catechin (chemistry), Down-Regulation (MeSH), Flavanones (metabolism), Mice (MeSH), Muscle Proteins (metabolism), Plants (chemistry), Receptors, Laminin (metabolism), Signal Transduction (MeSH), Tripartite Motif Proteins (metabolism), Ubiquitin-Protein Ligases (metabolism).
MESH :
- chemical , analogs & derivatives : Catechin.
- chemical , chemistry : Catechin.
- chemical , metabolism : Flavanones, Muscle Proteins, Receptors, Laminin, Tripartite Motif Proteins, Ubiquitin-Protein Ligases.
- chemistry : Plants.
- Animals, Down-Regulation, Mice, Signal Transduction.

Abstract

(-)-epigallocatechin-3-O-gallate (EGCG) is a bioactive polyphenol in green tea. Previous studies have demonstrated the beneficial effects of EGCG on muscle mass and muscle atrophy. In the current study, we investigated the mechanisms underlying effect of EGCG on muscle atrophy. It was demonstrated that EGCG suppressed muscle-specific ubiquitin ligase, muscle RING Finger 1 (MuRF1) expression through 67-kDa laminin receptor (67LR). Previous studies have shown that eriodictyol potentiates the anti-tumor activities of EGCG by amplifying 67LR signaling. Therefore, we investigated the effects of EGCG and eriodictyol on the MuRF1 expression in C2C12 myotubes. The combined treatment of EGCG and eriodictyol significantly suppressed MuRF1 expression in dexamethasone-treated C2C12 myotubes. Tail suspension was maintained for 10 consecutive days using C57BL6/J mice, and during this time EGCG and eriodictyol were orally administered. In the gastrocnemius muscle, the muscle mass loss was inhibited by the combination of EGCG and eriodictyol. Therefore, EGCG may prevent muscle atrophy by inducing 67LR signaling and eriodictyol amplifies this pathway.

DOI: 10.1007/s11418-020-01417-6
PubMed: 32472528

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000120
to stream Main, to step Curation: 000120

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">EGCG down-regulates MuRF1 expression through 67-kDa laminin receptor and the receptor signaling is amplified by eriodictyol.</title>
<author><name sortKey="Murata, Motoki" sort="Murata, Motoki" uniqKey="Murata M" first="Motoki" last="Murata">Motoki Murata</name>
<affiliation wicri:level="4"><nlm:affiliation>Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0305, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0305</wicri:regionArea>
<orgName type="university">Université de Kyūshū</orgName>
<placeName><settlement type="city">Fukuoka</settlement>
<region type="province">Kyūshū</region>
<region type="prefecture">Préfecture de Fukuoka</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Advanced Research Support Center (ADRES), Ehime University, Matsuyama, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Advanced Research Support Center (ADRES), Ehime University, Matsuyama</wicri:regionArea>
<wicri:noRegion>Matsuyama</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Shimizu, Yuki" sort="Shimizu, Yuki" uniqKey="Shimizu Y" first="Yuki" last="Shimizu">Yuki Shimizu</name>
<affiliation wicri:level="4"><nlm:affiliation>Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0305, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0305</wicri:regionArea>
<orgName type="university">Université de Kyūshū</orgName>
<placeName><settlement type="city">Fukuoka</settlement>
<region type="province">Kyūshū</region>
<region type="prefecture">Préfecture de Fukuoka</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Marugame, Yuki" sort="Marugame, Yuki" uniqKey="Marugame Y" first="Yuki" last="Marugame">Yuki Marugame</name>
<affiliation wicri:level="4"><nlm:affiliation>Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0305, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0305</wicri:regionArea>
<orgName type="university">Université de Kyūshū</orgName>
<placeName><settlement type="city">Fukuoka</settlement>
<region type="province">Kyūshū</region>
<region type="prefecture">Préfecture de Fukuoka</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Nezu, Ayaka" sort="Nezu, Ayaka" uniqKey="Nezu A" first="Ayaka" last="Nezu">Ayaka Nezu</name>
<affiliation wicri:level="4"><nlm:affiliation>Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0305, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0305</wicri:regionArea>
<orgName type="university">Université de Kyūshū</orgName>
<placeName><settlement type="city">Fukuoka</settlement>
<region type="province">Kyūshū</region>
<region type="prefecture">Préfecture de Fukuoka</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fujino, Konatsu" sort="Fujino, Konatsu" uniqKey="Fujino K" first="Konatsu" last="Fujino">Konatsu Fujino</name>
<affiliation wicri:level="4"><nlm:affiliation>Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0305, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0305</wicri:regionArea>
<orgName type="university">Université de Kyūshū</orgName>
<placeName><settlement type="city">Fukuoka</settlement>
<region type="province">Kyūshū</region>
<region type="prefecture">Préfecture de Fukuoka</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yamada, Shuhei" sort="Yamada, Shuhei" uniqKey="Yamada S" first="Shuhei" last="Yamada">Shuhei Yamada</name>
<affiliation wicri:level="4"><nlm:affiliation>Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0305, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0305</wicri:regionArea>
<orgName type="university">Université de Kyūshū</orgName>
<placeName><settlement type="city">Fukuoka</settlement>
<region type="province">Kyūshū</region>
<region type="prefecture">Préfecture de Fukuoka</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kumazoe, Motofumi" sort="Kumazoe, Motofumi" uniqKey="Kumazoe M" first="Motofumi" last="Kumazoe">Motofumi Kumazoe</name>
<affiliation wicri:level="4"><nlm:affiliation>Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0305, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0305</wicri:regionArea>
<orgName type="university">Université de Kyūshū</orgName>
<placeName><settlement type="city">Fukuoka</settlement>
<region type="province">Kyūshū</region>
<region type="prefecture">Préfecture de Fukuoka</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fujimura, Yoshinori" sort="Fujimura, Yoshinori" uniqKey="Fujimura Y" first="Yoshinori" last="Fujimura">Yoshinori Fujimura</name>
<affiliation wicri:level="4"><nlm:affiliation>Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0305, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0305</wicri:regionArea>
<orgName type="university">Université de Kyūshū</orgName>
<placeName><settlement type="city">Fukuoka</settlement>
<region type="province">Kyūshū</region>
<region type="prefecture">Préfecture de Fukuoka</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tachibana, Hirofumi" sort="Tachibana, Hirofumi" uniqKey="Tachibana H" first="Hirofumi" last="Tachibana">Hirofumi Tachibana</name>
<affiliation wicri:level="4"><nlm:affiliation>Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0305, Japan. tatibana@agr.kyushu-u.ac.jp.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0305</wicri:regionArea>
<orgName type="university">Université de Kyūshū</orgName>
<placeName><settlement type="city">Fukuoka</settlement>
<region type="province">Kyūshū</region>
<region type="prefecture">Préfecture de Fukuoka</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2020">2020</date>
<idno type="RBID">pubmed:32472528</idno>
<idno type="pmid">32472528</idno>
<idno type="doi">10.1007/s11418-020-01417-6</idno>
<idno type="wicri:Area/Main/Corpus">000120</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000120</idno>
<idno type="wicri:Area/Main/Curation">000120</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000120</idno>
<idno type="wicri:Area/Main/Exploration">000120</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">EGCG down-regulates MuRF1 expression through 67-kDa laminin receptor and the receptor signaling is amplified by eriodictyol.</title>
<author><name sortKey="Murata, Motoki" sort="Murata, Motoki" uniqKey="Murata M" first="Motoki" last="Murata">Motoki Murata</name>
<affiliation wicri:level="4"><nlm:affiliation>Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0305, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0305</wicri:regionArea>
<orgName type="university">Université de Kyūshū</orgName>
<placeName><settlement type="city">Fukuoka</settlement>
<region type="province">Kyūshū</region>
<region type="prefecture">Préfecture de Fukuoka</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Advanced Research Support Center (ADRES), Ehime University, Matsuyama, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Advanced Research Support Center (ADRES), Ehime University, Matsuyama</wicri:regionArea>
<wicri:noRegion>Matsuyama</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Shimizu, Yuki" sort="Shimizu, Yuki" uniqKey="Shimizu Y" first="Yuki" last="Shimizu">Yuki Shimizu</name>
<affiliation wicri:level="4"><nlm:affiliation>Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0305, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0305</wicri:regionArea>
<orgName type="university">Université de Kyūshū</orgName>
<placeName><settlement type="city">Fukuoka</settlement>
<region type="province">Kyūshū</region>
<region type="prefecture">Préfecture de Fukuoka</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Marugame, Yuki" sort="Marugame, Yuki" uniqKey="Marugame Y" first="Yuki" last="Marugame">Yuki Marugame</name>
<affiliation wicri:level="4"><nlm:affiliation>Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0305, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0305</wicri:regionArea>
<orgName type="university">Université de Kyūshū</orgName>
<placeName><settlement type="city">Fukuoka</settlement>
<region type="province">Kyūshū</region>
<region type="prefecture">Préfecture de Fukuoka</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Nezu, Ayaka" sort="Nezu, Ayaka" uniqKey="Nezu A" first="Ayaka" last="Nezu">Ayaka Nezu</name>
<affiliation wicri:level="4"><nlm:affiliation>Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0305, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0305</wicri:regionArea>
<orgName type="university">Université de Kyūshū</orgName>
<placeName><settlement type="city">Fukuoka</settlement>
<region type="province">Kyūshū</region>
<region type="prefecture">Préfecture de Fukuoka</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fujino, Konatsu" sort="Fujino, Konatsu" uniqKey="Fujino K" first="Konatsu" last="Fujino">Konatsu Fujino</name>
<affiliation wicri:level="4"><nlm:affiliation>Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0305, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0305</wicri:regionArea>
<orgName type="university">Université de Kyūshū</orgName>
<placeName><settlement type="city">Fukuoka</settlement>
<region type="province">Kyūshū</region>
<region type="prefecture">Préfecture de Fukuoka</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yamada, Shuhei" sort="Yamada, Shuhei" uniqKey="Yamada S" first="Shuhei" last="Yamada">Shuhei Yamada</name>
<affiliation wicri:level="4"><nlm:affiliation>Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0305, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0305</wicri:regionArea>
<orgName type="university">Université de Kyūshū</orgName>
<placeName><settlement type="city">Fukuoka</settlement>
<region type="province">Kyūshū</region>
<region type="prefecture">Préfecture de Fukuoka</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kumazoe, Motofumi" sort="Kumazoe, Motofumi" uniqKey="Kumazoe M" first="Motofumi" last="Kumazoe">Motofumi Kumazoe</name>
<affiliation wicri:level="4"><nlm:affiliation>Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0305, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0305</wicri:regionArea>
<orgName type="university">Université de Kyūshū</orgName>
<placeName><settlement type="city">Fukuoka</settlement>
<region type="province">Kyūshū</region>
<region type="prefecture">Préfecture de Fukuoka</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fujimura, Yoshinori" sort="Fujimura, Yoshinori" uniqKey="Fujimura Y" first="Yoshinori" last="Fujimura">Yoshinori Fujimura</name>
<affiliation wicri:level="4"><nlm:affiliation>Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0305, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0305</wicri:regionArea>
<orgName type="university">Université de Kyūshū</orgName>
<placeName><settlement type="city">Fukuoka</settlement>
<region type="province">Kyūshū</region>
<region type="prefecture">Préfecture de Fukuoka</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tachibana, Hirofumi" sort="Tachibana, Hirofumi" uniqKey="Tachibana H" first="Hirofumi" last="Tachibana">Hirofumi Tachibana</name>
<affiliation wicri:level="4"><nlm:affiliation>Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0305, Japan. tatibana@agr.kyushu-u.ac.jp.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0305</wicri:regionArea>
<orgName type="university">Université de Kyūshū</orgName>
<placeName><settlement type="city">Fukuoka</settlement>
<region type="province">Kyūshū</region>
<region type="prefecture">Préfecture de Fukuoka</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of natural medicines</title>
<idno type="eISSN">1861-0293</idno>
<imprint><date when="2020" type="published">2020</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term>
<term>Catechin (analogs & derivatives)</term>
<term>Catechin (chemistry)</term>
<term>Down-Regulation (MeSH)</term>
<term>Flavanones (metabolism)</term>
<term>Mice (MeSH)</term>
<term>Muscle Proteins (metabolism)</term>
<term>Plants (chemistry)</term>
<term>Receptors, Laminin (metabolism)</term>
<term>Signal Transduction (MeSH)</term>
<term>Tripartite Motif Proteins (metabolism)</term>
<term>Ubiquitin-Protein Ligases (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term>
<term>Catéchine (analogues et dérivés)</term>
<term>Catéchine (composition chimique)</term>
<term>Flavanones (métabolisme)</term>
<term>Plantes (composition chimique)</term>
<term>Protéines du muscle (métabolisme)</term>
<term>Protéines à motif tripartite (métabolisme)</term>
<term>Récepteur laminine (métabolisme)</term>
<term>Régulation négative (MeSH)</term>
<term>Souris (MeSH)</term>
<term>Transduction du signal (MeSH)</term>
<term>Ubiquitin-protein ligases (métabolisme)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Catechin</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Catechin</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Flavanones</term>
<term>Muscle Proteins</term>
<term>Receptors, Laminin</term>
<term>Tripartite Motif Proteins</term>
<term>Ubiquitin-Protein Ligases</term>
</keywords>
<keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Catéchine</term>
</keywords>
<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Plants</term>
</keywords>
<keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Catéchine</term>
<term>Plantes</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Flavanones</term>
<term>Protéines du muscle</term>
<term>Protéines à motif tripartite</term>
<term>Récepteur laminine</term>
<term>Ubiquitin-protein ligases</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Down-Regulation</term>
<term>Mice</term>
<term>Signal Transduction</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Régulation négative</term>
<term>Souris</term>
<term>Transduction du signal</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">(-)-epigallocatechin-3-O-gallate (EGCG) is a bioactive polyphenol in green tea. Previous studies have demonstrated the beneficial effects of EGCG on muscle mass and muscle atrophy. In the current study, we investigated the mechanisms underlying effect of EGCG on muscle atrophy. It was demonstrated that EGCG suppressed muscle-specific ubiquitin ligase, muscle RING Finger 1 (MuRF1) expression through 67-kDa laminin receptor (67LR). Previous studies have shown that eriodictyol potentiates the anti-tumor activities of EGCG by amplifying 67LR signaling. Therefore, we investigated the effects of EGCG and eriodictyol on the MuRF1 expression in C2C12 myotubes. The combined treatment of EGCG and eriodictyol significantly suppressed MuRF1 expression in dexamethasone-treated C2C12 myotubes. Tail suspension was maintained for 10 consecutive days using C57BL6/J mice, and during this time EGCG and eriodictyol were orally administered. In the gastrocnemius muscle, the muscle mass loss was inhibited by the combination of EGCG and eriodictyol. Therefore, EGCG may prevent muscle atrophy by inducing 67LR signaling and eriodictyol amplifies this pathway.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" IndexingMethod="Curated" Owner="NLM"><PMID Version="1">32472528</PMID>
<DateCompleted><Year>2020</Year>
<Month>10</Month>
<Day>06</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>10</Month>
<Day>06</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1861-0293</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>74</Volume>
<Issue>4</Issue>
<PubDate><Year>2020</Year>
<Month>Sep</Month>
</PubDate>
</JournalIssue>
<Title>Journal of natural medicines</Title>
<ISOAbbreviation>J Nat Med</ISOAbbreviation>
</Journal>
<ArticleTitle>EGCG down-regulates MuRF1 expression through 67-kDa laminin receptor and the receptor signaling is amplified by eriodictyol.</ArticleTitle>
<Pagination><MedlinePgn>673-679</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1007/s11418-020-01417-6</ELocationID>
<Abstract><AbstractText>(-)-epigallocatechin-3-O-gallate (EGCG) is a bioactive polyphenol in green tea. Previous studies have demonstrated the beneficial effects of EGCG on muscle mass and muscle atrophy. In the current study, we investigated the mechanisms underlying effect of EGCG on muscle atrophy. It was demonstrated that EGCG suppressed muscle-specific ubiquitin ligase, muscle RING Finger 1 (MuRF1) expression through 67-kDa laminin receptor (67LR). Previous studies have shown that eriodictyol potentiates the anti-tumor activities of EGCG by amplifying 67LR signaling. Therefore, we investigated the effects of EGCG and eriodictyol on the MuRF1 expression in C2C12 myotubes. The combined treatment of EGCG and eriodictyol significantly suppressed MuRF1 expression in dexamethasone-treated C2C12 myotubes. Tail suspension was maintained for 10 consecutive days using C57BL6/J mice, and during this time EGCG and eriodictyol were orally administered. In the gastrocnemius muscle, the muscle mass loss was inhibited by the combination of EGCG and eriodictyol. Therefore, EGCG may prevent muscle atrophy by inducing 67LR signaling and eriodictyol amplifies this pathway.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Murata</LastName>
<ForeName>Motoki</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0305, Japan.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Advanced Research Support Center (ADRES), Ehime University, Matsuyama, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Shimizu</LastName>
<ForeName>Yuki</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0305, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Marugame</LastName>
<ForeName>Yuki</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0305, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Nezu</LastName>
<ForeName>Ayaka</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0305, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Fujino</LastName>
<ForeName>Konatsu</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0305, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yamada</LastName>
<ForeName>Shuhei</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0305, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kumazoe</LastName>
<ForeName>Motofumi</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0305, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Fujimura</LastName>
<ForeName>Yoshinori</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0305, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tachibana</LastName>
<ForeName>Hirofumi</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0305, Japan. tatibana@agr.kyushu-u.ac.jp.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>JP15H02448</GrantID>
<Agency>Japan Society for the Promotion of Science</Agency>
<Country></Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2020</Year>
<Month>05</Month>
<Day>29</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>Japan</Country>
<MedlineTA>J Nat Med</MedlineTA>
<NlmUniqueID>101518405</NlmUniqueID>
<ISSNLinking>1340-3443</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D044950">Flavanones</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D009124">Muscle Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D017474">Receptors, Laminin</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000070584">Tripartite Motif Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>8R1V1STN48</RegistryNumber>
<NameOfSubstance UI="D002392">Catechin</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>BQM438CTEL</RegistryNumber>
<NameOfSubstance UI="C045651">epigallocatechin gallate</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.3.2.27</RegistryNumber>
<NameOfSubstance UI="C440908">TRIM63 protein, human</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.3.2.27</RegistryNumber>
<NameOfSubstance UI="D044767">Ubiquitin-Protein Ligases</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>Q520486B8Y</RegistryNumber>
<NameOfSubstance UI="C007619">eriodictyol</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002392" MajorTopicYN="N">Catechin</DescriptorName>
<QualifierName UI="Q000031" MajorTopicYN="Y">analogs & derivatives</QualifierName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015536" MajorTopicYN="N">Down-Regulation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D044950" MajorTopicYN="N">Flavanones</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009124" MajorTopicYN="N">Muscle Proteins</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010944" MajorTopicYN="N">Plants</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017474" MajorTopicYN="N">Receptors, Laminin</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000070584" MajorTopicYN="N">Tripartite Motif Proteins</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D044767" MajorTopicYN="N">Ubiquitin-Protein Ligases</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">67LR</Keyword>
<Keyword MajorTopicYN="N">EGCG</Keyword>
<Keyword MajorTopicYN="N">Eriodictyol</Keyword>
<Keyword MajorTopicYN="N">MuRF1</Keyword>
<Keyword MajorTopicYN="N">Muscle atrophy</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year>
<Month>02</Month>
<Day>25</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2020</Year>
<Month>05</Month>
<Day>17</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2020</Year>
<Month>5</Month>
<Day>31</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2020</Year>
<Month>10</Month>
<Day>7</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2020</Year>
<Month>5</Month>
<Day>31</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">32472528</ArticleId>
<ArticleId IdType="doi">10.1007/s11418-020-01417-6</ArticleId>
<ArticleId IdType="pii">10.1007/s11418-020-01417-6</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Japon</li>
</country>
<region><li>Kyūshū</li>
<li>Préfecture de Fukuoka</li>
</region>
<settlement><li>Fukuoka</li>
</settlement>
<orgName><li>Université de Kyūshū</li>
</orgName>
</list>
<tree><country name="Japon"><region name="Kyūshū"><name sortKey="Murata, Motoki" sort="Murata, Motoki" uniqKey="Murata M" first="Motoki" last="Murata">Motoki Murata</name>
</region>
<name sortKey="Fujimura, Yoshinori" sort="Fujimura, Yoshinori" uniqKey="Fujimura Y" first="Yoshinori" last="Fujimura">Yoshinori Fujimura</name>
<name sortKey="Fujino, Konatsu" sort="Fujino, Konatsu" uniqKey="Fujino K" first="Konatsu" last="Fujino">Konatsu Fujino</name>
<name sortKey="Kumazoe, Motofumi" sort="Kumazoe, Motofumi" uniqKey="Kumazoe M" first="Motofumi" last="Kumazoe">Motofumi Kumazoe</name>
<name sortKey="Marugame, Yuki" sort="Marugame, Yuki" uniqKey="Marugame Y" first="Yuki" last="Marugame">Yuki Marugame</name>
<name sortKey="Murata, Motoki" sort="Murata, Motoki" uniqKey="Murata M" first="Motoki" last="Murata">Motoki Murata</name>
<name sortKey="Nezu, Ayaka" sort="Nezu, Ayaka" uniqKey="Nezu A" first="Ayaka" last="Nezu">Ayaka Nezu</name>
<name sortKey="Shimizu, Yuki" sort="Shimizu, Yuki" uniqKey="Shimizu Y" first="Yuki" last="Shimizu">Yuki Shimizu</name>
<name sortKey="Tachibana, Hirofumi" sort="Tachibana, Hirofumi" uniqKey="Tachibana H" first="Hirofumi" last="Tachibana">Hirofumi Tachibana</name>
<name sortKey="Yamada, Shuhei" sort="Yamada, Shuhei" uniqKey="Yamada S" first="Shuhei" last="Yamada">Shuhei Yamada</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Bois/explor/PlantImRecepV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000167 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000167 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Bois
   |area=    PlantImRecepV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:32472528
   |texte=   EGCG down-regulates MuRF1 expression through 67-kDa laminin receptor and the receptor signaling is amplified by eriodictyol.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:32472528" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a PlantImRecepV1

This area was generated with Dilib version V0.6.38.
Data generation: Sat Nov 21 12:33:18 2020. Site generation: Sat Nov 21 12:33:47 2020

	Serveur d'exploration sur les récepteurs immunitaires végétaux
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur les récepteurs immunitaires végétaux

EGCG down-regulates MuRF1 expression through 67-kDa laminin receptor and the receptor signaling is amplified by eriodictyol.

EGCG down-regulates MuRF1 expression through 67-kDa laminin receptor and the receptor signaling is amplified by eriodictyol.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki